Depression commonly manifests physically, through stomach pains, headaches, disrupted or excessive sleep, and motor control difficulty. While the causes of depression are unknown, a predisposition for it runs in families and it can be triggered by trauma and adverse life circumstances. Depression is diagnosed more frequently in women and tends to display differently in women than in men.

People tend to suffer higher rates of depression after giving birth and in late fall. Depression and anxiety often exacerbate each other and people with depression commonly have difficulty concentrating on tasks and conversations. Some people abuse alcohol and drugs or overeat as a way of coping, causing them to develop other medical problems. Depressed people are also at increased risk for self-harm.